Sex ratio and heterozygote advantage in cystic fibrosis families.

Heterozygote Advantage for Fecundity

Heterozygote advantage, or overdominance, remains a popular and persuasive explanation for the maintenance of genetic variation in natural populations in the face of selection. However, despite being first proposed more than 80 years ago, there remain few examples that fit the criteria for heterozygote advantage, all of which are associated with disease resistance and are maintained only in the...

Novel CFTR Mutations in Two Iranian Families with Severe Cystic Fibrosis

Background: Cystic fibrosis (CF) is a common autosomal recessive disorder that affects many body systems and is produced by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. CF is also the most frequently inherited disorder in the West. The aim of this study was to detect the mutations in the CFTR gene in two Iranian families with CF. Methods: After DNA extractio...

The Selective Advantage of Sex-Ratio Homeostasis

No Heterozygote Advantage in Fallow Deer

Effects of inbreeding on individual fitness are of long-standing interest in evolutionary biology and conservation studies. Since estimation of the inbreeding coefficient of a given individual is often impossible in wild populations, some authors have attempted to demonstrate inbreeding depression in such populations by correlating the multi-locus marker heterozygosity of individuals with a tra...

Nutritional Assesment in Cystic Fibrosis Patients( Iran and Newzeland)

Introduction: Patients with Cystic Fibrosis have increased risk of malnutrition. Early detection of nutritional deterioration enables prompt intervention and correction. The aims of this project were to: - Define the nutritional status of CF patients in Iran and New Zealand -    Compare and contrast the MacDonald Nutritional Screening tool  with the Australasian guidelines for Nutrition in Cyst...